中文版 | 英文版

劳动卫生与环境卫生学系

张遵真

发布时间 :2022-06-22      来源 :       浏览量 :

基本情况

张遵真,医学博士,四川大学华西公共卫生学院劳动卫生与环境卫生学系,教授,博士研究生导师,四川省学术技术带头人,四川省卫生健康委环境与健康首席专家。

社会任职

四川省中华预防医学会环境卫生分会常委;四川省预防医学学会环境卫生分委会主任委员;中国医院建设及装备协会医院水系统学组专家;四川省环境科学学会理事,四川省成都市环境学会主任委员。《四川大学学报(医学版)》、《环境卫生学杂志》、《中国食品卫生杂志》编委,《预防医学情报杂志》副主编。

研究方向

(1)长期研究环境与健康,特别是环境污染物诱导氧化应激在致癌机制中的作用;近年致力于表观遗传学解析环境暴露与人群健康效应;

(2)精通环境健康风险评价和环境卫生标准研制的理论与实践,在环境污染物致癌评价理论方面深有建树;

(3)善长环境因素“有利与有害”效应辨析,熟悉保健食品、化妆品、消毒剂等的毒性评价和植物提取物的功能性评价理论与实践。

成果简介

作为负责人主持过6个国家自然科学基金项目,多个四川省科技厅和成都市科技局科研项目;发表科研论文近300篇,其中60多篇发表在国际环境科学、毒理学、药理学类主流期刊,具有较好影响力。参编过《环境卫生学》、《现代环境卫生学》、《中华医学百科全书环境卫生学》等教科书、教辅书的章节。

联系方式:电子邮箱,zhangzz@scu.edu.cn,手机:13689067422

【科研项目】

  1. 国家自然科学基金委员会,面上项目,82073510,N6-甲基腺苷结合蛋白YTHDF2相分离在砷诱导氧化应激中的作用和机制,2021.1-2024.12,56万元,在研,主持

  2. 四川省科技厅,重点项目,2020YJ0230,FAS和PPARα作为非酒精性脂肪性肝病联合治疗靶点的作用及机制研究。2020-2022,40万,在研,主持

  3. 国家自然科学基金委员会,面上项目,81773380,N6-甲基腺苷通过P53信号通路参与砷诱导细胞恶性转化的机制研究,2018.01-2021.12,50万元,已结题,主持

  4. 国家自然科学基金委员会,面上项目,81372945,P53蛋白二阶段磷酸化修饰在砷“致癌与治癌”双重作用中的机制研究,2014.01-2017.12,70万元,已结题,主持

  5. 成都市科技局,惠民项目,2015-HM01-00064-SF,成都市高校学生安全教育现状与高校安全教育评估体系的建立,2015.12-2017.12,10万元,已结题,主持

  6. 国家自然科学基金委员会,面上项目,Nrf2-AREs和NF-κB信号通路及其交互作用在低水平砷诱导细胞凋亡中的作用,81172632,2014.01-2017-12,70万元,已结题,主持

  7. 国家自然科学基金委员会,面上项目,30872079,DNA聚合酶β表达水平的改变在环境污染物遗传毒性中的作用,2009-01至2011-12,32万元,已结题,主持

  8. 国家自然科学基金委员会,面上项目,30571535,HOGG1低表达细胞株的建立及其在DNA氧化损伤与肺癌相关性中的研究,2006-01至2008-12,27万元,已结题,主持

【代表性学术成果】

  1. Donglei Sun, Chao Zuo, Wei Huang, Jingjing Wang, Zunzhen Zhang, Triclosan targeting of gut microbiome ameliorates hepatic steatosis in high fat diet-fed mice, The Journal of Antibiotics,2022,https://doi.org/10.1038/s41429-022-00522-w,

  2. 王婷,孙东雷,赵田禾,张遵真.中国直饮水及相关卫生标准比较分析,四川大学学报(医学版),2021,52(5):729-734。

  3. Ting Wang, Donglei Sun, Qian Zhang, Zunzhen Zhang*.China's drinking water sanitation from 2007 to 2018: A systematic review. Science of the Total Environment, 2121,757:143923.

  4. Donglei Sun, Tianhe Zhao, Keyan Long, Mei Wu, Zunzhen Zhang. Triclosan down-regulates fatty acid synthase through microRNAs in HepG2 cells, European Journal of Pharmacology,2021;907:174261...

  5. 左超,孙东雷,王静静,黄维,张遵真,三氯生改善非酒精性脂肪性肝病小鼠的肝脏脂肪沉积,现代预防医学,2021.48:22,4176-4180

  6. Tianhe Zhao, Donglei Sun, Manyu Zhao,Yanhao Lai, Yuan Liu,and Zunzhen Zhang.N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53activation. Environmental pollution,2020,259:113908,

  7. Donglei Sun, Tianhe Zhao, Ting Wang, Mei Wu and Zunzhen Zhang. Genotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test. Environmental science and pollution research.2020, 27:7430-7438

  8. Xinyang Li, Donglei Sun, Tianhe Zhao, Zunzhen Zhang. Long non coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression. European journal of pharmacology, 2020,872:172982

  9. Xinyang Li, Zuo Chao, Donglei Sun, Tianhe Zhao, Zunzhen Zhang. Arsenite increases Linc-ROR in human bronchial epithelial cells that can be inhibited by antioxidant factors. Biological trace element research,2020 ;198(1):131-141.

  10. Xinyang Li, Zuo Chao, Mei Wu, Zunzhen Zhang. Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity. metallomics, 2020, 12, 963-973.

  11. Donglei Sun, Tianhe Zhao, Qian Zhang, Mei Wu, and Zunzhen Zhang.Fat mass and obesity-associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA. Cell Biol Int., 2020;1-11.

  12. Hongyu Chen, Tianhe Zhao, Donglei Sun, Mei Wu, Zunzhen Zhang. Changes of RNA N6-methyladenosine in the hormesis effect induced by arsenite on human keratinocyte cells. Toxicology in vitro, 2019,56:84-92.

  13. Tianhe Zhao, Xinyang Li, Donglei Sun, Zunzhen Zhang.Oxidative stress: One potential factor for arsenite-induced increase of N6-methyladenosine in human keratinocytes. Environmental Toxicology and Pharmacology, 2019,69:95-103.

  14. Donglei Sun, Tianhe Zhao, Xinyang Li & Zunzhen Zhang. Evaluation of DNA and chromosomal damage in two human HaCaT and L02 cells treated with varying triclosan concentrations. Journal of Toxicology and Environmental Health, Part A Current Issues. 2019;82(7):473-482

  15. Donglei Sun, Tianhe Zhao, Ting Wang, Mei Wu and Zunzhen ZhangGenotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test.Environmental science and pollution research.2019, 12yue online,DOI/org/10.1007/sii356-019-07351-9

  16. Shiyan Gu, Donglei Sun, Huangmei Dai, Zunzhen Zhang.N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells. Toxicology Letters, 2018,292:1-11.

  17. Shiyan Gu, Donglei Sun, Xinyang Li, Zunzhen Zhang. Alterations of miRNAs and their potential roles in arsenite-induced transformation of human bronchial epithelial cells. Genes (Basel) , 2017, 8(10): E254.

  18. Shiyan Gu, Yanhao Lai, Hongyu Chen, Yuan Liu, Zunzhen Zhang. miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells. Sci Rep. 2017, 7(1): 12155.

  19. Chengzhi Chen, Xuejun Jiang, Shiyan Gu, Zunzhen Zhang. MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. Toxicology Letters, 2017, 278: 38-47.

  20. Tianhe Zhao; Lichun Wu; Xinyang Li, Huangmei Dai and Zunzhen Zhang._Large intergenic non-coding RNA-ROR as a potential biomarker for the diagnosis and dynamic monitoring of breast cancer. Cancer Biomarkers, 2017, 20:165-173.

  21. Qingyin Luo, Jill M. Beaver, Yuan Liu and Zunzhen Zhang. Dynamics of p53: A Master Decider of Cell Fate. Genes, 2017, 2017 Feb 9;8(2), pii: E66.

  22. Hongyu Chen, Shiyan Gu, Huangmei Dai, Xinyang Li, Zunzhen Zhang, Dihydroartemisinin Sensitizes Human Lung Adenocarcinoma A549 Cells to Arsenic Trioxide via Apoptosis. Biol Trace Elem Res, 2017,179(2)203-212.

  23. Xuejun Jianga, Chengzhi Chena, Shiyan Gu, Zunzhen Zhang, Regulation of ABCG2 by nuclear factor kappa B affects the sensitivity of human lung adenocarcinoma A549 cells to arsenic trioxide. Environmental Toxicology and Pharmacology,2018,57: 141–150

  24. Chengzhi Chen, Shiyan Gu, Xuejun Jiang, Zunzhen Zhang. Nuclear translocation of nuclear factor kappa B is regulated by G protein signaling pathway in arsenite-induced apoptosis in HBE cell line. Environ Toxicol. 2016, 31(12):1819-1833.

  25. Shiyan Gu, Chengzhi Chen, Xuejun Jiang, Zunzhen Zhang. ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells. Chem Biol Interact. 2016,245,100-109.

  26. Chengzhi Chen, Shiyan Gu, Xuejun Jiang, Zunzhen Zhang,Arsenite-Induced Endoplasmic Reticulum-Dependent Apoptosis Through Disturbance of Calcium Homeostasis in HBE Cell Line,Environmental Toxicology,2017,32:197-216.

  27. Chengzhi Chen, Xuejun Jiang, Shiyan Gu, Yanhao Lai, Yuan Liu, Zunzhen Zhang. Protection of Nrf2 Against Arsenite-induced Oxidative Damage is Regulated by the Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Pathway. Environmental Toxicology,Environ Toxicol. 2017, 32(8):2004-2020.

【获奖情况】

2022年,被中国科技论文在线评为2021年中国科技论文在线评审的优秀评审专家;

2021年,获得四川大学指导本科毕业论文三等奖;

2020年,张遵真老师在四川大学2019年本科教学工作中成绩突出,获得课堂教学质量优秀奖;

2016年:张遵真老师在2015年四川大学课程考试改革中,居室与健康成绩突出,获得非标准答案考试命题优秀奖;

2016年:张遵真在四川大学2015-2016学年学生学术型社团指导工作中成绩突出,荣获学术型社团指导教师鼓励奖;

2013年:张遵真老师,在四川大学2012年本科教学工作中成绩突出,被评委文化素质公选课最受欢迎教师;

2013年:指导的毕业论文获2008届优秀毕业论文三等奖。


上一条:张勤
下一条:王永伟