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陈锦瑶

发布时间 :2018-10-08      来源 :       浏览量 :

【基本情况】

营养与食品卫生学博士,副教授,营养与食品卫生学系副主任。研究方向食品中有毒有害物质的遗传毒性研究;食品安全风险评估;植物化学物的功能评价研究。美国马里兰大学访问学者。现任国家食品安全风险评估专家委员会委员,中华预防医学卫生毒理学分会委员,中国营养学会营养毒理学分会常务委员等。

【目前承担课程】

基础营养学、食品毒理学、食品卫生学、食品卫生学实践、专业英语(食品卫生与营养学)、专业英语(预防医学)、食品安全与健康(研究生课程)、现代毒理学(研究生课程)、食品安全风险分析(研究生课程)等

【主要科研成果】

目前共负责国家级、省部级项目及横向项目20项,发表研究论文50余篇,其中SCI期刊收录论文20篇,参编专著/教材十余本。

2014年迄今共负责项目20项:

1.体内多终点遗传毒性实验系统的建立与应用研究(2018-2020):四川大学建设世界一流大学专项创新火花库项目(项目编号:2018SCUH0005)

2.游离糖的危害评估(2018):国家食品安全风险评估中心委托项目 (项目编号:18H0446)

3.呋喃及甲基呋喃等3种物质危害评估(2018):国家食品安全风险评估中心委托项目 (项目编号:18H0416)

4.海洋鱼骨胶原低聚肽和天门冬氨酸钙复合物增强骨密度的研究(2018):横向项目(项目编号:18H0274)

5.交链孢毒素危害评估(2018):国家食品安全风险评估中心委托项目 (项目编号:18H0336)

6.壬基酚的发育免疫毒性及其机制研究(2018-2020):国家自然科学基金青年科学基金(项目编号:81703258)

7.双酚A和双酚S双酚F的危害评估工作(2017-2018):国家食品安全风险评估中心委托项目 (项目编号:17H0754)

8.水飞蓟和葛根联合作用改善酒精性肝纤维化功能评价及机制研究(2017~2019):汤臣倍健营养科学研究基金(项目编号:TY0161104)

9.中药降尿酸功能方法建立及应用研究(2016-2017):四川省中医药科学技术研究青年专项项目(项目编号:2016Q045)

10.砷危害评估和暴露评估数据库构建以及铬和苯甲酸危害评估(2016):国家食品安全风险评估中心委托项目(项目编号:16H0754)

11.体内Pig-a基因突变试验的优化与验证(2015-2016):四川大学青年教师科研启动基金(项目编号:2015SCU11010)

12.四川省地方标准制定—香辛料中赭曲霉毒素A的测定(2015-2016):四川省卫生计生委(项目编号:2015WJW-05)

13.益生菌调节肠道菌群功能学评价研究(2015):横向项目(项目编号:15H0213)

14.开展壬基酚危害识别和参考值确定(2015):国家食品安全风险评估中心委托项目(项目编号:15H0783)

15. 7.四川省主要禾谷类作物真菌毒素污染谱的遗传毒性风险评估(2019~2020):四川省科技厅课题(项目编号:2019YJ0020)

主要发表文章

1.Chen, J.Y. Reply to T. Kawada: Cadmium exposure and renal effect. J Appl Toxicol. 2020 Dec;40(12):1705-1706. doi: 10.1002/jat.4107. Epub 2020 Nov 3.

2.Wu R, Zhong S, Ni M, Zhu X, Chen Y, Chen X, Zhang L, Chen J. Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice. Evid Based Complement Alternat Med. 2020 Sep 15;2020:8617143. doi: 10.1155/2020/8617143.

3.Li R, Tan Y, Li Y, Zhu X, Tang X, Zhang L, Chen J. Effects of Tart Cherry Powder on Serum Uric Acid in Hyperuricemia Rat Model. Evid Based Complement Alternat Med. 2020 Jul 22;2020:1454305. doi: 10.1155/2020/1454305. eCollection 2020.

4.Huo, J., Liu, Y., Zhu, X., Zeng, Z., Chen, Y., Li, R., . . . Chen, J. (2020). 2-Methylfuran: Toxicity and genotoxicity in male Sprague-Dawley rats. Mutat Res, 854-855, 503209. doi:10.1016/j.mrgentox.2020.503209

5.Chen, Y., Huo, J., Liu, Y., Zeng, Z., Zhu, X., Chen, X., . . . Chen, J. (2020). Development of a novel flow cytometry-based approach for reticulocytes micronucleus test in rat peripheral blood. J Appl Toxicol. doi:10.1002/jat.4068

6.Dai, J., Yang, X., Yuan, Y., Jia, Y., Liu, G., Lin, N., Zhang L.S., Chen, J.Y. (2020). Toxicity, gut microbiota and metabolome effects after copper exposure during early life in SD rats. Toxicology, 152395. doi:10.1016/j.tox.2020.152395.

7.Wang H, Li X, Li Rj, Chen, J.Y. *, Zhang, L.S*. Association of exposure to metals with the risk of hypertension among an older population aged 40–75 years in rural southwest China. J Appl Toxicol. 2020;1–11. https://doi.org/10.1002/jat.3968

8.Li, X.M., Li, R.J., Yan, J.M., Song, Y., Huo, J., Lan, Z., Chen, J.Y. *, Zhang, L.S*. Co-exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40-75 years. Journal of Applied Toxicology 2020,40(3):352-362.

9.Cheng, S.P., Sun, H.X., Li, X.M., Yan, J.M., Peng, Z.H., You, Y.P., Zhang, L.S.*, Chen, J.Y*. Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats. Evidence-Based Complementary and Alternative Medicine vol. 2019, https://doi.org/10.1155/2019/4541609

10.Yan J.M, Huo J., Li R.J., Jia Z.C., Song Y., Chen J.Y., Zhang L.S.. Benchmark dose estimation of urinary and blood cadmium as biomarkers of renal dysfunction among 40-75-year-old nonsmoking women in rural areas of southwest China. J Appl Toxicol. 2019; 39 (10), 1433-1443.

11.Li X.M., Liu Y.J., Yue W.Y., Tan Y.F., Wang H., Zhang L.S., Chen J.Y. A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway. 2019. Evidence-Based Complementary and Alternative Medicine https://doi.org/10.1155/2019/9121347.

12.Li X.M., Huo J., Liu Z.P., Yue Q.L, Zhang L.S, Gong Y.Y., Chen J.Y.*, Bao H.H. An updated weight of evidence approach for deriving a health-based guidance value for 4-nonylphenol[J]. Journal of applied toxicology 39 (1), 87-100,2019.

13.Huo J, Huang Z, Li R, Song Y, Lan Z, Ma S, Chen J.Y., Zhang L.S.. (2018) Dietary cadmium exposure assessment in rural areas of Southwest China. PLoS ONE 13(8): e0201454. https://doi.org/10.1371/journal.pone.0201454.

14.Ni M., You Y., Chen J.Y., Zhang L.S. Copper in depressive disorder: A systematic review and meta-analysis of observational studies. Psychiatry Research 267 (2018) 506–515.

15.Huo J., Yang H., Lu Y.D., Ma S.J., Cheng W.B., Li X.M., Chen J.Y., Zhang L.S. Establishment of rat models for screening slow-acting drugs of hyperuricemia. Int J Clin Exp Med 2018;11(2):830-839.

16.Chen J.Y., Huo J., Jia Z.C., Yang Song Y., Li Y., Zhang L.S. Effects of Atrazine on the Proliferation and Cytotoxicity of Murine Lymphocytes with the use of Carboxyfluorescein Succinimidyl Ester-based Flow Cytometric Approaches. Food and Chemical Toxicology. 2015 8;76C:61-69.

【获奖情况】

1.2017年“TK基因突变试验推广应用”获教育部高等学校科学研究优秀成果奖(推广类)二等奖(排名第二)。